S-box is one of the key components in block cipher algorithm， and its confounding and scrambling effect determines security strength of the whole cipher. In order to ensure better cryptographic performance of S-boxes generated based on chaotic systems， a dynamic S-box design scheme based on anti-degradation chaotic system was proposed. Firstly， Chebyshev chaotic map was disturbed by Lorenz chaotic map. Then， two initial S-boxes were generated by interception method and interval partition method. Finally， the final S-box was obtained by using index sort perturbation method. The chaotic sequences generated by anti-degenerate chaotic system do not have phenomenon of short cycle， and have characteristics of ergodic property and unpredictability. When applying these sequences to the design of S-box， the safety performance of S-box can be greatly improved， and the hidden danger of chaos generation source can be eliminated. Moreover， dynamic S-boxes can be generated in batches by adjusting system parameters. The safety performance of S-box， including nonlinearity， difference uniformity， strict avalanche criterion， output bits independence criterion and bijective characteristics， was tested and compared. Experimental results show that the S-box generated by the proposed scheme has better cryptographic performance and can be used in design of block cipher.